Results
| PMID | 8653926 |
| Gene Name | IL6R |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 64 |
| Population details | 64 (29 patients with endometriosis, 31 patients with benign ovarian masses, 4 patients with chronic inflammation or adhesions) |
| Sex | Female |
| Associated genes | IL-6,sIL-6R |
| Other associated phenotypes |
Endometriosis |
|
Clin Exp Obstet Gynecol. 1996;23(1):10-4. Schroder, W| Gaetje, R| Baumann, R Frauenklinik der Medizinischen Einrichtungen, Rheinisch-Westfalischen Technischen Hochschule, Aachen. OBJECTIVE: Interleukin-6 (IL-6) and soluble Interleukin-6-receptor (sIL-6R) concentrations were investigated in patients with endometriosis and other benign gynecologic diseases. METHODS: During laparoscopy or laparotomy peritoneal fluid and serum were collected from 29 patients with endometriosis, 31 patients with benign ovarian masses and 4 patients with chronic inflammation or adhesions. Interleukin-6 (IL-6) concentrations were determined by Elisa-technique. RESULTS: Patients with endometriosis stage IV revealed slightly higher IL-6 concentrations in peritoneal fluid when compared to patients with stage I to II disease and ovarian masses/ chronic inflammation. IL-6 serum concentrations were higher in case of stage I and II when compared to stage III and IV and ovarian masses/chronic inflammation. Patients with endometriosis revealed significantly higher sIL-6 receptor concentrations in peritoneal fluid and serum as compared to patients with ovarian cysts and chronic inflammation. CONCLUSION: IL-6 and soluble IL-6 receptor may be considered to be involved in endometriosis. However, the patho-physiologic mechanism must be the subject of further investigation. Mesh Terms: Adolescent| Adult| Aged| Ascitic Fluid/*chemistry| Endometriosis/*metabolism/pathology| Female| Humans| Interleukin-6/*analysis/blood| Middle Aged| Ovarian Diseases/metabolism| Receptors, Interleukin/*analysis|DA 1996/01/01 00:01 |
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